World Malaria Day (WMD) is an international observance commemorated every year on 25 April and recognizes global efforts to control malaria. Globally, 3.3 billion people in 106 countries are at risk of malaria. In 2012, malaria caused an estimated 627,000 deaths, mostly among African children. Asia, Latin America, and to a lesser extent the Middle East and parts of Europe are also affected.

World Day for Safety and Health at Work is a UN international day that is celebrated every 28 April.

Italy's Liberation Day (Festa della liberazione), also known as the Anniversary of the Liberation (Anniversario della liberazione d'Italia), Anniversary of the Resistance (anniversario della Resistenza), or simply 25 April is a national Italian holiday commemorating the end of the Italian Civil War and the end of Nazi occupation of the country during World War II. This is distinct from the Republic Day (Festa della Repubblica) which takes place on 2 June.

International Dance Day was introduced in 1982 by the International Dance Council (CID, Conseil International de la Danse), a UNESCO partner NGO, and is celebrated yearly, on April 29. The date is not linked to a particular person or a particular form of dance, although it's also the day when the French dancer and ballet master Jean-Georges Noverre was born. The main purpose of Dance Day events is to attract the attention of the wider public to the art of dance. Emphasis should be given to addressing a new public, people who do not follow dance events during the course of the year.

On this day, April 12, in 1961, a citizen of the Soviet Union, Major Yuri Gagarin by spaceship "Vostok" for the first time in the world made orbital flight of the Earth, opening the era of manned space flights. He made one turn around the Earth that continued 108 minutes.

The development of manned flights is in stages with the progress of scientific and technological results and new scientific, economic and technical problems. From the first manned spacecraft and space stations to multi-purpose space manned orbital complex - this is the way traversed by the Soviet manned space flights.

Cosmonautics Bright successes - the natural result of selfless work of many thousands of people, dozens of labor groups, who do all they can for the progress of the space industry.

According to the decision of the International Aeronautical Federation the April, 12 is the International Day of Aviation and Cosmonautics.

In Ukraine, this day is called the Day of the space industry of Ukraine and fixed by Presidential Decree ? 230/97of March 13, 1997, respectively, its celebration is held every year on April 12.

International Jazz Day is a yearly event on 30 April, organized by UNESCO to celebrate “the virtues of jazz as an educational tool, and a force for peace, unity, dialogue and enhanced cooperation among people.”

The Day was proclaimed during the UNESCO General Conference in November 2011. The first annual International Jazz Day was kicked off in Paris by UNESCO Director-General Irina Bokova and UNESCO Goodwill Ambassador Herbie Hancock.

According to the United Nations Educational, Scientific and Cultural Organization (UNESCO), for more than a century jazz has helped soothe and uplift the souls of millions of people in all corners of the world. And so, it is no wonder that the UN’s cultural arm has organized International Jazz Day to harness “the virtues of jazz as an educational tool, and a force for peace, unity, dialogue and enhanced cooperation among people.” Since 2012, International Jazz Day, celebrated annually on 30 April, has highlighted the power of this musical art form as a force for freedom and creativity, promoting intercultural dialogue through respect and understanding and uniting people from all corners of the globe.

World Book Day or World Book and Copyright Day (also known as International Day of the Book or World Book Days) is a yearly event on April 23rd, organized by the United Nations Educational, Scientific and Cultural Organization (UNESCO), to promote reading, publishing and copyright. In the United Kingdom, the day is recognized on the first Thursday in March. World Book Day was celebrated for the first time on 23 April 1995.

International Day for Mine Awareness celebrated on April 4.

National Maritime Day of India celebrated on 5th April.

World Intellectual Property Day is observed annually on 26 April. The event was established by the World Intellectual Property Organization (WIPO) in 2000 to "raise awareness of how patents, copyright, trademarks and designs impact on daily life" and "to celebrate creativity, and the contribution made by creators and innovators to the development of societies across the globe". 26 April was chosen as the date for World Intellectual Property Day because it coincides with the date on which the Convention Establishing the World Intellectual Property Organization entered into force in 1970.