Q: Which statement is true about the IgM of humans?  

Answer: D

Immunoglobulin M (IgM) is the largest immunoglobulin and is the first immunoglobulin to be produced in response to an antigen. It is primarily restricted in the circulation and is not able to cross the placenta. IgM is produced by high-affinity plasma cells and is able to protect the mucosal surface.

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